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Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection

机译：逆转录酶K70E和K65R突变的病毒突变体在长期替诺福韦单药长期治疗恒河猴猕猴的替诺福韦单药治疗中的出现和临床意义

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Pedersen Niels C; Matthews Timothy B; Marthas Marta L; Lipscomb Jonathan; Singh Raman P; Blackwood Emily J; Johnson Jeffrey A; Van Rompay Koen KA; Bischofberger Norbert; Heneine Walid; North Thomas W;
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1. Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection [J] . Koen KA Van Rompay, Jeffrey A Johnson, Emily J Blackwood, Retrovirology . 2007,第S1期

机译：在长期RT-SHIV感染恒河猴中长期替诺福韦单药治疗期间，逆转录酶中具有K70E和K65R突变的病毒突变体的顺序出现和临床意义
2. Molecular basis of antagonism between K70E and K65R tenofovir-associated mutations in HIV-1 reverse transcriptase. [J] . Kagan RM, Lee TS, Ross L, Antiviral Research . 2007,第3期

机译：HIV-1逆转录酶中K70E和K65R替诺福韦相关突变之间的拮抗作用的分子基础。
3. Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal [J] . Koen K A Van Rompay, Kristin A Trott, Kartika Jayashankar, Retrovirology . 2012,第S1期

机译：长时间替诺福韦治疗感染SIV K65R逆转录酶突变体的猕猴会导致抗病毒免疫反应的发展，该反应可控制停药后的病毒复制
4. Part I: Synthesis of Cyclobutyl Nucleoside Analogs That Mimic AZT for Inhibition of the K65R HIV-1 Reverse Transcriptase Mutant. Part II: Synthesis and Evaluation of Truncated Triptolide Analogs to Suppress Chronic Inflammation [D] . Bluemling, Gregory Richard 2011

机译：第一部分：模拟AZT抑制K65R HIV-1逆转录酶突变体的环丁基核苷类似物的合成。第二部分：截短雷公藤甲素类似物的合成和评估，以抑制慢性炎症
5. Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection [O] . Koen KA Van Rompay, Jeffrey A Johnson, Emily J Blackwood, 2007

机译：逆转录酶K70E和K65R突变的病毒突变体在长期替诺福韦单药长期治疗恒河猴猕猴的替诺福韦单药治疗中的出现和临床意义
6. Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection [O] . Koen KA Van Rompay, Jeffrey A Johnson, Emily J Blackwood, 2007

机译：逆转录酶K70E和K65R突变的病毒突变体在长期替诺福韦单药长期治疗恒河猴猕猴的替诺福韦单药治疗中的出现和临床意义

Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection

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